All::Endocrinology::Diseases::Gitelman's syndrome

Intro

What are the main clinical features of Gitelman's syndrome?

  • normotension
  • hypokalaemia
  • hypocalciuria
  • hypomagnesaemia
  • metabolic alkalosis

What is the pathophysiology of Gitelman's syndrome?

defect in the thiazide-sensitive Na+ Cl- transporter in the distal convoluted tubule