What is the inheritance pattern of Bartter's syndrome?

usually autosomal recessive

What are the main clinical features of Bartter's syndrome?

• usually presents in childhood, e.g. Failure to thrive
• polyuria, polydipsia
• hypokalaemia
• normotension
• weakness

What is the pathophysiology of Bartter's syndrome?

severe hypokalaemia due to defective chloride absorption at the Na+ K+ 2Cl- cotransporter (NKCC2) in the ascending loop of Henle