All::Endocrinology::Pharmacology::Meglitinides
Intro
What is the drug class of repaglinide, nateglinide?
Meglitinides
What is the method of action of Meglitinides?
they bind to an ATP-dependent K+(KATP) channel on the cell membrane of pancreatic beta cells
What is the main clinical use of Meglitinides?
increase pancreatic insulin secretion
often used for patients with an erratic lifestyle
What are the main adverse effects of Meglitinides?
weight gain and hypoglycaemia (less so than sulfonylureas)