What is Reye's syndrome?

a severe, progressive encephalopathy affecting children that is accompanied by fatty infiltration of the liver, kidneys and pancreas

What is the peak incidence of Reye's syndrome?

2 years

What medication is associated with Reye's syndrome?

aspirin use

What are the features of Reye's syndrome?

• there may be a history of preceding viral illness
• encephalopathy: confusion, seizures, cerebral oedema, coma
• fatty infiltration of the liver, kidneys and pancreas
• hypoglycaemia

What is the management of Reye's syndrome?

supportive

What is the mortality of Reye's syndrome?

~15-25%