What is the common presentation of Maturity-Onset Diabetes of the Young?

• mild non-ketotic hyperglycemia that is often detected incidentally or during routine screening
• may also be discovered during pregnancy

What is the inheritance pattern of Maturity-Onset Diabetes of the Young?

autosomal dominant

What patient groups is Maturity-Onset Diabetes of the Young most common?

usually before 25 years of age

What is the management of Maturity-Onset Diabetes of the Young?

• Depends on subtype, often does not require treatment.
• sulfonylureas and insulin can be used

What are the main causes of Maturity-Onset Diabetes of the Young?

Caused by gene mutation, 14 are currently known.

Most common cause is MODY3 gene (60%)

What is the pathophysiology of Maturity-Onset Diabetes of the Young?

ineffective insulin production or release by pancreatic beta cells