What is Multiple endocrine neoplasia?

a condition which encompasses several distinct syndromes featuring tumours of endocrine glands

What is the inheritance pattern of Multiple endocrine neoplasia?

autosomal dominant

What cancers are associated with MEN type I?

• Parathyroid (95%): hyperparathyroidism due to parathyroid hyperplasia
• Pituitary (70%)
• Pancreas (50%): e.g. insulinoma, gastrinoma (leading to recurrent peptic ulceration)

What cancers are associated with MEN type IIa?

• Medullary thyroid cancer (70%)
• Parathyroid (60%)
• Phaeochromocytoma

What cancers are associated with MEN type IIb?

• Medullary thyroid cancer
• Phaeochromocytoma
• Neuromas