What is Zollinger-Ellison syndrome?

condition characterised by excessive levels of gastrin, usually from a gastrin secreting tumour usually of the duodenum or pancreas

What are the main clinical features of Zollinger-Ellison syndrome?

• multiple gastroduodenal ulcers
• diarrhoea
• malabsorption

How is Zollinger-Ellison syndrome diagnosed?

• fasting gastrin levels: the single best screen test
• secretin stimulation test

What are the main associations of Zollinger-Ellison syndrome?

Around 30% occur as part of MEN type I syndrome