What is VIPoma?

a rare endocrine tumor that overproduces vasoactive intestinal peptide

What is the common presentation of VIPoma?

• large volume diarrhoea
• weight loss

cause a specific syndrome:

• dehydration
• hypokalemia
• hypercalcemia
• hyperglycemia
• achlorhydria
• acidosis
• flushing
• hypotension (from vasodilation)

How is VIPoma diagnosed?

fasting VIP plasma level

What are the main associations of VIPoma?

sometimes associated with multiple endocrine neoplasia type 1

What is the function of vasoactive intestinal peptide (VIP) in the GI system?

• smooth muscle relaxation (lower esophageal sphincter, stomach, gallbladder)
• stimulate secretion of water into pancreatic juice and bile
• cause inhibition of gastric acid secretion and absorption from the intestinal lumen