What are the first line Selective serotonin reuptake inhibitors in depression?

• citalopram
• fluoxetine

Which Selective serotonin reuptake inhibitor is best used post myocardial infarction?

sertraline

Which Selective serotonin reuptake inhibitor is used first line in children?

Fluoxetine

What is the most common side effect of Selective serotonin reuptake inhibitors?

gastrointestinal symptoms

What are the side effects of Selective serotonin reuptake inhibitors?

• gastrointestinal symptoms
• gastrointestinal bleeding
• increased anxiety and agitation after starting
• hyponatraemia

Which Selective serotonin reuptake inhibitors must be avoided in patients with long QT syndrome?

citalopram and escitalopram

What are the main Interactions with Selective serotonin reuptake inhibitors?

• warfarin / heparin/NSAIDs/aspirin: Due to risk of GI bleed
• triptans/monoamine oxidase inhibitors - increased risk of serotonin syndrome

How soon after starting an antidepressant should it be reviewed?

2 weeks

After resolution of symptoms how much longer should patients stay on antidepressants for?

6 months to reduce the risk of relapse

How do you stop a Selective serotonin reuptake inhibitor to minimise withdrawal symptoms?

tamper down slowly over 4 weeks

What are the withdrawal symptoms of Selective serotonin reuptake inhibitors?

• increased mood change
• restlessness
• difficulty sleeping
• unsteadiness
• sweating
• gastrointestinal symptoms
• paraesthesia

What are the risks of using Selective serotonin reuptake inhibitors during the first trimester?

a small increased risk of congenital heart defects

What are the risks of using Selective serotonin reuptake inhibitors during the third trimester?

can result in persistent pulmonary hypertension of the newborn

What are the risks of using Paroxetine during Pregnancy?

increased risk of congenital malformations