All::Rheumatology::Diseases::Paget's disease of the bone
Intro
What is Paget's disease primarily characterized by?
Increased, uncontrolled bone turnover, mainly a disorder of osteoclasts.
What are common sites affected by Paget's disease?
Skull, spine/pelvis, and long bones of the lower extremities.
What factors predispose individuals to Paget's disease?
Increasing age, male sex, northern latitude, and family history.
What are typical clinical features of Paget's disease?
Bone pain (pelvis, lumbar spine, femur), raised alkaline phosphatase (ALP), bowing of tibia, and bossing of the skull.
What complications can arise from Paget's disease?
The text does not provide information on complications.
What complications can arise from Paget's disease involving the skull?
Deafness due to cranial nerve entrapment, skull thickening.
What potential serious complication is associated with long-term Paget's disease?
Bone sarcoma, with a 1% risk if affected for more than 10 years.
What cardiovascular complication can occur with Paget's disease?
High-output cardiac failure.
What skeletal complications are associated with Paget's disease?
Fractures due to bone involvement.