All::Rheumatology::Diseases::Pseudogout
Intro
What is the more accurate term for pseudogout?
Acute calcium pyrophosphate crystal deposition disease.
What causes pseudogout, and what crystals are deposited?
Pseudogout is caused by the deposition of calcium pyrophosphate dihydrate crystals in the synovium.
What age group is strongly associated with pseudogout?
Pseudogout is strongly associated with increasing age.
What are some underlying risk factors for developing pseudogout at a younger age (< 60 years)?
Haemochromatosis, hyperparathyroidism, low magnesium, low phosphate, acromegaly, Wilson's disease.
Which joints are most commonly affected by pseudogout?
Knee, wrist, and shoulders are most commonly affected.
What is the characteristic finding in joint aspiration for pseudogout?
Weakly-positively birefringent rhomboid-shaped crystals.
What radiographic finding is associated with pseudogout?
Chondrocalcinosis, seen as linear calcifications of the meniscus and articular cartilage, especially in the knee.
How is pseudogout managed?
Aspiration of joint fluid to exclude septic arthritis, and use of NSAIDs or intra-articular, intra-muscular, or oral steroids as for gout.