All::Rheumatology::Diseases::Sjogren's syndrome
Intro
What is Sjogren's syndrome?
An autoimmune disorder affecting exocrine glands, causing dry mucosal surfaces.
Who does Sjogren's syndrome primarily affect?
It is much more common in females (ratio 9:1).
What is the increased risk associated with Sjogren's syndrome?
Marked increased risk of lymphoid malignancy (40-60 fold).
What are the common features of Sjogren's syndrome?
Dry eyes, dry mouth, vaginal dryness, arthralgia, Raynaud's, myalgia, sensory polyneuropathy, recurrent parotitis, and subclinical renal tubular acidosis.
Which antibodies are often positive in Sjogren's syndrome?
Anti-Ro (SSA) antibodies (70% in primary Sjogren's), anti-La (SSB) antibodies (30%), RF (50%), and ANA (70%).
How is tear formation measured in Sjogren's syndrome?
Schirmer's test, placing filter paper near the conjunctival sac to measure tear production.
What is the management for Sjogren's syndrome?
Artificial saliva and tears, and pilocarpine may stimulate saliva production.