What an example of Serotonin 5-HT3-receptor antagonists?

Ondansetron

What is the method of action of Serotonin 5-HT3-receptor antagonists?

• Blocking 5-HT3 receptors in the CTZ
• Blocking 5-HT3 receptors in the gut (these are involved in responding to emetogenic stimuli)

What is the main clinical use of Serotonin 5-HT3-receptor antagonists?

Nausea and vomiting, particularly in the context of general anaesthesia and chemotherapy

What are the main contraindications of Serotonin 5-HT3-receptor antagonists?

Prolonged QT interval