Acute interstitial nephritis accounts for {{c1::25%}} of drug-induced acute kidney injury

What are the drug causes of Acute interstitial nephritis?

• penicillin
• rifampicin
• NSAIDs
• allopurinol
• furosemide

What are the systemic disease causes of Acute interstitial nephritis?

• SLE
• sarcoidosis
• Sjögren's syndrome

What are the infective causes of Acute interstitial nephritis?

Hanta virus , staphylococci

What is the histological findings in Acute interstitial nephritis?

marked interstitial oedema and interstitial infiltrate in the connective tissue between renal tubules

What symptoms might Acute interstitial nephritis present with?

fever, rash, arthralgia

What changes are seen on bloods with Acute interstitial nephritis?

• eosinophilia
• mild renal impairment

What changes are seen in urine with Acute interstitial nephritis?

• sterile pyuria
• white cell casts

What is Acute interstitial nephritis?

is acute inflammation of the renal tubulo-interstitium

What is the treatment for Acute interstitial nephritis?

May resolve once the triggering medication is discontinued. Corticosteroid therapy may be associated with greater recovery of kidney function.

What are the lasting side effects from Acute interstitial nephritis?

Most patients have some residual renal impairment after an episode of acute interstitial nephritis.