What is Membranoproliferative glomerulonephritis?

• a type of glomerulonephritis
• caused by deposits in the kidney glomerular mesangium and basement membrane thickening, activating complement and damaging the glomeruli

What is mesangiocapillary glomerulonephritis?

alternative name for Membranoproliferative glomerulonephritis

What would show on renal biopsy in Membranoproliferative glomerulonephritis?

subendothelial and mesangium immune deposits of electron-dense material resulting in a 'tram-track' appearance

What is Type II Membranoproliferative glomerulonephritis?

Now know as dense deposit disease or C3 nephropathy associated with deposition of complement C3 within the glomeruli with little or no staining for immunoglobulins

What causes dense deposit disease? ‘C3 nephropathy’

caused by uncontrolled complement alternative pathway activation

Whats the prognosis of dense deposit disease? ‘C3 nephropathy’

• Spontaneous remissions are rare
• about half of those affected will progress to end stage renal disease within ten years

What would show on renal biopsy in dense deposit disease? ‘C3 nephropathy’

intramembranous immune complex deposits with 'dense deposits'