All::Cardiovascular System::Pharmacology::Nicorandil

Intro

What is the drug class of Nicorandil

An anti-anginal medicine (a potassium-channel activator)

What is the method of action of Nicorandil

a potassium-channel activator with vasodilation is through activation of guanylyl cyclase which results in increase cGMP

What is the main clinical use of Nicorandil

to treat angina

What is the main adverse effects of Nicorandil

  • headache
  • flushing
  • skin, mucosal and eye ulceration
  • gastrointestinal ulcers including anal ulceration

What is the main contraindications of Nicorandil

left ventricular failure