What is the drug class of Cyclophosphamide

alkylating agent

What is the main clinical use of Cyclophosphamide

management of cancer and autoimmune conditions

What is the main adverse effects of Cyclophosphamide

• haemorrhagic cystitis: incidence reduced by the use of hydration and mesna
• myelosuppression
• transitional cell carcinoma

What is Mesna? (Drug)

used in those taking cyclophosphamide or ifosfamide to decrease the risk of bleeding from the bladder

Why does cyclophosphamide cause haemorrhagic cystitis?

a metabolite of cyclophosphamide called acrolein is toxic to urothelium