What are the main clinical features of Acute myeloid leukaemia?

Features are largely related to bone marrow failure:

• anaemia: pallor, lethargy, weakness
• neutropenia: whilst white cell counts may be very high, functioning neutrophil levels may be low leading to frequent infections etc
• thrombocytopenia: bleeding
• splenomegaly
• bone pain

What age group is more commonly affected by Acute myeloid leukaemia?

older adults

What are the Poor prognostic features of Acute myeloid leukaemia?

• over 60 years
• more than 20% blasts after first course of chemo
• cytogenetics: deletions of chromosome 5 or 7

Classification - French-American-British (FAB) of Acute myeloid leukaemia

• MO - {{c1::undifferentiated}}
• M1 - {{c2::without maturation}}
• M2 - {{c3::with granulocytic maturation}}
• M3 - {{c4::acute promyelocytic}}
• M4 - {{c5::granulocytic and monocytic maturation}}
• M5 - {{c6::monocytic}}
• M6 - {{c7::erythroleukaemia}}
• M7 - {{c8::megakaryoblastic}}